Polymorphisms of the ICAM-1 gene are associated with inflammatory bowel disease, regardless of the p-ANCA status
C Braun, R Zahn, K Martin, E Albert, C Folwaczny - Clinical Immunology, 2001 - Elsevier
The intercellular adhesion molecule-1 (ICAM-1) is of paramount importance for the initiation
and propagation of various inflammatory conditions. An increased frequency of allele R241
of the ICAM-1 gene was previously described in p-ANCA-negative as compared to p-ANCA-
positive ulcerative colitis and vice versa in Crohn's disease. One hundred sixteen healthy
unrelated controls, 121 patients with ulcerative colitis, and 96 patients with Crohn's disease
were genotyped for two polymorphisms of the ICAM-1 gene (R/G241, exon 4; and K/E469 …
and propagation of various inflammatory conditions. An increased frequency of allele R241
of the ICAM-1 gene was previously described in p-ANCA-negative as compared to p-ANCA-
positive ulcerative colitis and vice versa in Crohn's disease. One hundred sixteen healthy
unrelated controls, 121 patients with ulcerative colitis, and 96 patients with Crohn's disease
were genotyped for two polymorphisms of the ICAM-1 gene (R/G241, exon 4; and K/E469 …