[HTML][HTML] Differential kinetic and spatial patterns of β-arrestin and G protein-mediated ERK activation by the angiotensin II receptor
S Ahn, SK Shenoy, H Wei, RJ Lefkowitz - Journal of Biological Chemistry, 2004 - ASBMB
The seven-membrane-spanning angiotensin II type 1A receptor activates the mitogen-
activated protein kinases extracellular signal-regulated kinases 1 and 2 (ERK1/2) by distinct
pathways dependent on either G protein (likely G q/G 11) or β-arrestin2. Here we sought to
distinguish the kinetic and spatial patterns that characterize ERK1/2 activated by these two
mechanisms. We utilized β-arrestin RNA interference, the protein kinase C inhibitor Ro-31-
8425, a mutant angiotensin II receptor (DRY/AAY), and a mutant angiotensin II peptide (SII …
activated protein kinases extracellular signal-regulated kinases 1 and 2 (ERK1/2) by distinct
pathways dependent on either G protein (likely G q/G 11) or β-arrestin2. Here we sought to
distinguish the kinetic and spatial patterns that characterize ERK1/2 activated by these two
mechanisms. We utilized β-arrestin RNA interference, the protein kinase C inhibitor Ro-31-
8425, a mutant angiotensin II receptor (DRY/AAY), and a mutant angiotensin II peptide (SII …