[HTML][HTML] G protein-coupled receptors: III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization
RJ Lefkowitz - Journal of Biological Chemistry, 1998 - ASBMB
Of the many forms of GPCR1 regulation none has received as much attention as the process
of receptor desensitization, ie the waning responsiveness of the receptors in the face of
persistent stimulation (1, 2). Numerous mechanisms have been discovered, including those
that operate at the transcriptional, translational, and protein levels. The latter category in turn
includes mechanisms that regulate the rate of degradation of the receptors. Finally, there are
mechanisms for the covalent modification of the receptors as well as for the regulation of …
of receptor desensitization, ie the waning responsiveness of the receptors in the face of
persistent stimulation (1, 2). Numerous mechanisms have been discovered, including those
that operate at the transcriptional, translational, and protein levels. The latter category in turn
includes mechanisms that regulate the rate of degradation of the receptors. Finally, there are
mechanisms for the covalent modification of the receptors as well as for the regulation of …