[HTML][HTML] Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid is a hydrophobically stabilized nitric oxide donor
The aqueous decay and concomitant release of nitric oxide (· NO) by nitrolinoleic acid (10-
nitro-9, 12-octadecadienoic acid and 12-nitro-9, 12-octadecadienoic acid; LNO 2) are
reported. Mass spectrometric analysis of reaction products supports a modified Nef reaction
as the mechanism accounting for the generation of· NO by the aqueous reactions of fatty
acid nitroalkene derivatives. Nitrolinoleic acid is stabilized by an aprotic milieu, with LNO 2
decay and· NO release strongly inhibited by phosphatidylcholine/cholesterol liposome …
nitro-9, 12-octadecadienoic acid and 12-nitro-9, 12-octadecadienoic acid; LNO 2) are
reported. Mass spectrometric analysis of reaction products supports a modified Nef reaction
as the mechanism accounting for the generation of· NO by the aqueous reactions of fatty
acid nitroalkene derivatives. Nitrolinoleic acid is stabilized by an aprotic milieu, with LNO 2
decay and· NO release strongly inhibited by phosphatidylcholine/cholesterol liposome …