[HTML][HTML] Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer
R Mehra, SA Tomlins, R Shen, O Nadeem, L Wang… - Modern Pathology, 2007 - Elsevier
Novel recurrent gene fusions between the androgen-regulated gene TMPRSS2 and the ETS
family members ERG, ETV1, or ETV4 have been recently identified as a common molecular
event in prostate cancer development. We comprehensively analyzed the frequency and risk
of disease progression for the TMPRSS2 and ETS family genes rearrangements in a cohort
of 96 American men surgically treated for clinically localized prostate cancer. Using three
break apart (TMPRSS2, ERG, ETV4) and one fusion (TMPRSS: ETV1) fluorescence in situ …
family members ERG, ETV1, or ETV4 have been recently identified as a common molecular
event in prostate cancer development. We comprehensively analyzed the frequency and risk
of disease progression for the TMPRSS2 and ETS family genes rearrangements in a cohort
of 96 American men surgically treated for clinically localized prostate cancer. Using three
break apart (TMPRSS2, ERG, ETV4) and one fusion (TMPRSS: ETV1) fluorescence in situ …