Prostate cancer is unique among the potentially lethal human malignancies in the wide
discrepancy between the high prevalence of histologic changes recognizable as cancer and
the much lower prevalence of the clinical disease. Despite the availability of effective tests
for early detection and of effective treatment for cancers so detected, the diagnosis usually is
not established until the tumor is locally advanced or metastatic. Yet, physicians hesitate to
use these tests for fear that many cancers found would be latent, of little threat to the life or …