[HTML][HTML] Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53 (–/–) HCT-116 colon cancer cells to …
ZP Lin, MF Belcourt, JG Cory, AC Sartorelli - Journal of Biological Chemistry, 2004 - ASBMB
Ribonucleotide reductase catalyzes the production of deoxyribonucleoside diphosphates,
the precursors of deoxyribonucleoside triphosphates for DNA synthesis. Mammalian
ribonucleotide reductase (RNR) is a tetramer consisting of two non-identical homodimers,
R1 and either R2 or p53R2, which are considered to be involved in DNA replication and
repair, respectively. We have demonstrated that DNA damage by doxorubicin and cisplatin
caused a steady elevation of the R2 protein in p53 (–/–) HCT-116 human colon carcinoma …
the precursors of deoxyribonucleoside triphosphates for DNA synthesis. Mammalian
ribonucleotide reductase (RNR) is a tetramer consisting of two non-identical homodimers,
R1 and either R2 or p53R2, which are considered to be involved in DNA replication and
repair, respectively. We have demonstrated that DNA damage by doxorubicin and cisplatin
caused a steady elevation of the R2 protein in p53 (–/–) HCT-116 human colon carcinoma …