[HTML][HTML] Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity
RA Finch, MC Liu, AH Cory, JG Cory… - Advances in enzyme …, 1999 - Elsevier
Ribonucleotide reductase (EC 1.17. 4.1; RR) plays a central role in the de novo synthesis of
deoxyribonucleotides required for DNA replication and repair (1, 2) and there is a strong
correlation between the activity of the enzyme and the rate of cellular replication (3, 4). As
such, RR offers a particularly attractive target for neoplastic agents directed against rapidly
growing tumors. The mammalian enzyme is composed of two protein dimer subunits,
referred to as M1 and M2. The catalytic core of the M2 subunit contains a tyrosyl free radical …
deoxyribonucleotides required for DNA replication and repair (1, 2) and there is a strong
correlation between the activity of the enzyme and the rate of cellular replication (3, 4). As
such, RR offers a particularly attractive target for neoplastic agents directed against rapidly
growing tumors. The mammalian enzyme is composed of two protein dimer subunits,
referred to as M1 and M2. The catalytic core of the M2 subunit contains a tyrosyl free radical …