[HTML][HTML] Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells
P Håkansson, A Hofer, L Thelander - Journal of Biological Chemistry, 2006 - ASBMB
Ribonucleotide reductase (RNR) provides the cell with a balanced supply of
deoxyribonucleoside triphosphates (dNTP) for DNA synthesis. In budding yeast DNA
damage leads to an up-regulation of RNR activity and an increase in dNTP pools, which are
essential for survival. Mammalian cells contain three non-identical subunits of RNR; that is,
one homodimeric large subunit, R1, carrying the catalytic site and two variants of the
homodimeric small subunit, R2 and the p53-inducible p53R2, each containing a tyrosyl free …
deoxyribonucleoside triphosphates (dNTP) for DNA synthesis. In budding yeast DNA
damage leads to an up-regulation of RNR activity and an increase in dNTP pools, which are
essential for survival. Mammalian cells contain three non-identical subunits of RNR; that is,
one homodimeric large subunit, R1, carrying the catalytic site and two variants of the
homodimeric small subunit, R2 and the p53-inducible p53R2, each containing a tyrosyl free …