[HTML][HTML] Regulation of the promoter activity of interferon regulatory factor-7 gene: activation by interferon and silencing by hypermethylation
R Lu, WC Au, WS Yeow, N Hageman… - Journal of Biological …, 2000 - ASBMB
The molecular mechanism by which virus induces expression of the early inflammatory
genes has not yet been completely elucidated. Previous studies indicated that the virus-
mediated transcription of type I interferon (IFN) genes required activation of two members of
IFN regulatory factor (IRF) family, IRF-3 and IRF-7, where the expression of IRF-7 was found
to be indispensable for the induction of IFNA genes. To determine the factors that regulate
expression of IRF-7 gene, as well as its inducibility by type I IFNs, we have isolated and …
genes has not yet been completely elucidated. Previous studies indicated that the virus-
mediated transcription of type I interferon (IFN) genes required activation of two members of
IFN regulatory factor (IRF) family, IRF-3 and IRF-7, where the expression of IRF-7 was found
to be indispensable for the induction of IFNA genes. To determine the factors that regulate
expression of IRF-7 gene, as well as its inducibility by type I IFNs, we have isolated and …