[HTML][HTML] Disabled-2 exerts its tumor suppressor activity by uncoupling c-Fos expression and MAP kinase activation
J He, ER Smith, XX Xu - Journal of Biological Chemistry, 2001 - ASBMB
Disabled-2 (Dab2) is a putative tumor suppressor in breast and ovarian cancers. Its
expression is lost in a majority of tumors, and homozygous deletions have been identified in
a small percentage of tumors. Dab2 expression is absent or very low in the majority of breast
and ovarian cancer cell lines, including MCF-7 and SK-Br-3 breast cancer cells. Transfection
and expression of Dab2 in MCF-7 and SK-Br-3 cells suppress tumorigenicity. The cells
reach a much lower saturation density and have reduced ability to form colonies on agar …
expression is lost in a majority of tumors, and homozygous deletions have been identified in
a small percentage of tumors. Dab2 expression is absent or very low in the majority of breast
and ovarian cancer cell lines, including MCF-7 and SK-Br-3 breast cancer cells. Transfection
and expression of Dab2 in MCF-7 and SK-Br-3 cells suppress tumorigenicity. The cells
reach a much lower saturation density and have reduced ability to form colonies on agar …