[HTML][HTML] Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling
Suppressors of cytokine signaling (SOCS) are Src homology-2-containing proteins originally
identified as negative regulators of cytokine signaling. Accumulating evidence indicates a
role for SOCS proteins in the regulation of additional signaling pathways including receptor
tyrosine kinases. Notably, SOCS36E, the Drosophila ortholog of mammalian SOCS5, was
recently implicated as a negative regulator of the Drosophila ortholog of EGFR. In this study,
we aimed at characterizing the role of SOCS5 in the negative regulation of EGFR. Here we …
identified as negative regulators of cytokine signaling. Accumulating evidence indicates a
role for SOCS proteins in the regulation of additional signaling pathways including receptor
tyrosine kinases. Notably, SOCS36E, the Drosophila ortholog of mammalian SOCS5, was
recently implicated as a negative regulator of the Drosophila ortholog of EGFR. In this study,
we aimed at characterizing the role of SOCS5 in the negative regulation of EGFR. Here we …