Expression of mRNA for DNA methyltransferases and methyl-CpG–binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions …
Y Saito, Y Kanai, M Sakamoto, H Saito, H Ishii… - Hepatology, 2001 - Elsevier
To evaluate the significance of alterations in DNA methylation during human
hepatocarcinogenesis, we examined levels of mRNA for DNA methyltransferases and
methyl-CpG-binding proteins and the DNA methylation status in 67 hepatocellular
carcinomas (HCCs). The average level of mRNA for DNMT1 and DNMT3a was significantly
higher in noncancerous liver tissues showing chronic hepatitis or cirrhosis than in
histologically normal liver tissues, and was even higher in HCCs. Significant overexpression …
hepatocarcinogenesis, we examined levels of mRNA for DNA methyltransferases and
methyl-CpG-binding proteins and the DNA methylation status in 67 hepatocellular
carcinomas (HCCs). The average level of mRNA for DNMT1 and DNMT3a was significantly
higher in noncancerous liver tissues showing chronic hepatitis or cirrhosis than in
histologically normal liver tissues, and was even higher in HCCs. Significant overexpression …