Fatty acid synthase and adipsin mRNA levels in obese and lean JCR: LA-cp rats: effect of diet.
G Shillabeer, J Hornford, JM Forden, NC Wong… - Journal of lipid …, 1992 - ASBMB
In Sprague-Dawley rats, fatty acid synthase (FAS) activity is suppressed by dietary fat. To
test the hypothesis that a defect in regulation of de novo fatty acid synthesis exists in
massive obesity, we investigated the effect of diet on FAS mRNA levels in genetically obese
JCR: LA-corpulent (cp) rats. We also determined levels of mRNA encoding adipsin, a fat cell-
derived protein possibly associated with lipid metabolism. Hepatic FAS mRNA levels were
elevated five-fold in obese compared to lean cp rats and were unsuppressed by dietary fat …
test the hypothesis that a defect in regulation of de novo fatty acid synthesis exists in
massive obesity, we investigated the effect of diet on FAS mRNA levels in genetically obese
JCR: LA-corpulent (cp) rats. We also determined levels of mRNA encoding adipsin, a fat cell-
derived protein possibly associated with lipid metabolism. Hepatic FAS mRNA levels were
elevated five-fold in obese compared to lean cp rats and were unsuppressed by dietary fat …