Mitochondria establish contact sites between the inner and outer membranes. The contact
sites are held together by junctional complexes of the adenine nucleotide translocase (ANT;
inner membrane) and the voltage-dependent anion channel (VDAC; outer membrane). The
junctional complexes act as multifunctional recruitment centres, binding a range of proteins
according to the function to be executed. Some of these, involving kinases and enzymes of
lipid transfer, are readily understood as ongoing functions in energy and lipid metabolism …