The effects of cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory therapy on 24-hour blood pressure in patients with hypertension, osteoarthritis, and type …
JR Sowers, WB White, B Pitt, A Whelton… - Archives of Internal …, 2005 - jamanetwork.com
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 (COX-2)
inhibitors may attenuate the efficacy of antihypertensive agents in high-risk patients.
Therefore, we conducted a double-blind, randomized trial to evaluate the effects of
celecoxib, rofecoxib, and naproxen on 24-hour blood pressure (BP) in patients with type 2
diabetes, hypertension, and osteoarthritis. Methods Patients were randomly assigned to
treatment with 200 mg of celecoxib once daily (n= 136), 25 mg of rofecoxib once daily (n …
inhibitors may attenuate the efficacy of antihypertensive agents in high-risk patients.
Therefore, we conducted a double-blind, randomized trial to evaluate the effects of
celecoxib, rofecoxib, and naproxen on 24-hour blood pressure (BP) in patients with type 2
diabetes, hypertension, and osteoarthritis. Methods Patients were randomly assigned to
treatment with 200 mg of celecoxib once daily (n= 136), 25 mg of rofecoxib once daily (n …