Bcl-2 regulates nonapoptotic signal transduction: Inhibition of c-Jun N-terminal kinase (JNK) activation by IL-1β and hydrogen peroxide
We have explored the role of bcl-2 as a potential modulator of intracellular signal
transduction. Stable expression of bcl-2 in fibroblasts inhibited the activation of the c-jun
amino terminal kinase (JNK) by the nonapoptotic cytokine interleukin-1β (IL-1β). This effect
appeared to be selective for JNK activation as bcl-2 did not appear to alter other aspects of
IL-1β signal transduction. Similarly, bcl-2 did not inhibit all activators of JNK as it had no
effect on JNK activation by the protein synthesis inhibitor anisomycin. Treatment with …
transduction. Stable expression of bcl-2 in fibroblasts inhibited the activation of the c-jun
amino terminal kinase (JNK) by the nonapoptotic cytokine interleukin-1β (IL-1β). This effect
appeared to be selective for JNK activation as bcl-2 did not appear to alter other aspects of
IL-1β signal transduction. Similarly, bcl-2 did not inhibit all activators of JNK as it had no
effect on JNK activation by the protein synthesis inhibitor anisomycin. Treatment with …