[HTML][HTML] The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity
A Mueller, BW Schäfer, S Ferrari, M Weibel… - Journal of Biological …, 2005 - ASBMB
Head and neck squamous cell carcinoma express high levels of the EF-hand calcium-
binding protein S100A2 in contrast to other tumorigenic tissues and cell lines where the
expression of this protein is reduced. Subtractive hybridization of tumorigenic versus normal
tumor-derived mammary epithelial cells has previously identified the S100A2 protein as
potential tumor suppressor. The biological function of S100A2 in carcinogenesis, however,
has not been elucidated to date. Here, we report for the first time that during recovery from …
binding protein S100A2 in contrast to other tumorigenic tissues and cell lines where the
expression of this protein is reduced. Subtractive hybridization of tumorigenic versus normal
tumor-derived mammary epithelial cells has previously identified the S100A2 protein as
potential tumor suppressor. The biological function of S100A2 in carcinogenesis, however,
has not been elucidated to date. Here, we report for the first time that during recovery from …