[HTML][HTML] GATA-1-and FOG-dependent activation of megakaryocytic αIIB gene expression
P Gaines, JN Geiger, G Knudsen, D Seshasayee… - Journal of Biological …, 2000 - ASBMB
FOG is a multitype zinc finger protein that is essential for megakaryopoiesis, binds to the
amino-terminal finger of GATA-1, and modulates the transcription of GATA-1 target genes.
Presently investigated are effects of FOG and GATA-1 on the transcription of the
megakaryocytic integrin gene, αIIb. In GATA-1-deficient FDCER cells (in the presence of
endogenous FOG), ectopically expressed GATA-1 activated transcription 3–10-fold both
from αIIbtemplates and the endogenous αIIb gene. The increased expression of FOG …
amino-terminal finger of GATA-1, and modulates the transcription of GATA-1 target genes.
Presently investigated are effects of FOG and GATA-1 on the transcription of the
megakaryocytic integrin gene, αIIb. In GATA-1-deficient FDCER cells (in the presence of
endogenous FOG), ectopically expressed GATA-1 activated transcription 3–10-fold both
from αIIbtemplates and the endogenous αIIb gene. The increased expression of FOG …