Multipotent human hematopoietic cell line K562: lineage-specific constitutive and inducible antigens
JF Leary, BM Ohlsson-Wilhelm, R Giuliano, S Labella… - Leukemia research, 1987 - Elsevier
K562 cells have been reported to display a variety of non-erythroid properties. Using 28
lineage-specific monoclonal antibodies, we analysed which antigens are present
spontaneously and which are inducible by a variety of agents. The data suggest that (1)
antigens of a given lineage are preferentially responsive to certain inducers, eg
megakaryocytic antigens to phorbol ester, and (2) a given inducer may influence antigens of
different lineages in opposite directions, eg phorbol dibutyrate, not only induces …
lineage-specific monoclonal antibodies, we analysed which antigens are present
spontaneously and which are inducible by a variety of agents. The data suggest that (1)
antigens of a given lineage are preferentially responsive to certain inducers, eg
megakaryocytic antigens to phorbol ester, and (2) a given inducer may influence antigens of
different lineages in opposite directions, eg phorbol dibutyrate, not only induces …