C. elegans has served as a genetically tractable multicellular model system to examine DNA
damage-induced genotoxic stress which threatens genome integrity. Importantly, the high
degree of conservation shared between worms and humans offers the advantage that
findings about DNA damage-induced cell cycle arrest/checkpoint response and DNA double-
strand break repair in worms are applicable to human studies. Here, we describe simple
DNA damage sensitivity assays to quantify the response of C. elegans to diverse types of …