[HTML][HTML] Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis
Y Yasui, T Urano, A Kawajiri, K Nagata… - Journal of Biological …, 2004 - ASBMB
Mitotic kinases regulate cell division and its checkpoints, errors of which can lead to
aneuploidy or genetic instability. One of these is Aurora-B, a key kinase that is required for
chromosome alignment at the metaphase plate and for cytokinesis in mammalian cells. We
report here that human Aurora-B is phosphorylated at Thr-232 through interaction with the
inner centromere protein (INCENP) in vivo. The phosphorylation of Thr-232 occurs by
means of an autophosphorylation mechanism, which is indispensable for the Aurora-B …
aneuploidy or genetic instability. One of these is Aurora-B, a key kinase that is required for
chromosome alignment at the metaphase plate and for cytokinesis in mammalian cells. We
report here that human Aurora-B is phosphorylated at Thr-232 through interaction with the
inner centromere protein (INCENP) in vivo. The phosphorylation of Thr-232 occurs by
means of an autophosphorylation mechanism, which is indispensable for the Aurora-B …