[HTML][HTML] Dual-functional significance of ATM-mediated phosphorylation of spindle assembly checkpoint component Bub3 in mitosis and the DNA damage response
M Xiao, S Zhang, Z Liu, Y Mo, H Wang, X Zhao… - Journal of Biological …, 2022 - ASBMB
Both the DNA damage response (DDR) and the mitotic checkpoint are critical for the
maintenance of genomic stability. Among proteins involved in these processes, the ataxia–
telangiectasia mutated (ATM) kinase is required for both activation of the DDR and the
spindle assembly checkpoint (SAC). In mitosis without DNA damage, the enzymatic activity
of ATM is enhanced; however, substrates of ATM in mitosis are unknown. Using stable
isotope labeling of amino acids in cell culture mass spectrometry analysis, we identified a …
maintenance of genomic stability. Among proteins involved in these processes, the ataxia–
telangiectasia mutated (ATM) kinase is required for both activation of the DDR and the
spindle assembly checkpoint (SAC). In mitosis without DNA damage, the enzymatic activity
of ATM is enhanced; however, substrates of ATM in mitosis are unknown. Using stable
isotope labeling of amino acids in cell culture mass spectrometry analysis, we identified a …