[HTML][HTML] Interplay between the DNA damage proteins MDC1 and ATM in the regulation of the spindle assembly checkpoint
Y Eliezer, L Argaman, M Kornowski, M Roniger… - Journal of Biological …, 2014 - ASBMB
To avoid genomic instability, cells have developed surveillance mechanisms such as the
spindle assembly checkpoint (SAC) and the DNA damage response. ATM and MDC1 are
central players of the cellular response to DNA double-strand breaks. Here, we identify a
new role for these proteins in the regulation of mitotic progression and in SAC activation.
MDC1 localizes at mitotic kinetochores following SAC activation in an ATM-dependent
manner. ATM phosphorylates histone H2AX at mitotic kinetochores, and this …
spindle assembly checkpoint (SAC) and the DNA damage response. ATM and MDC1 are
central players of the cellular response to DNA double-strand breaks. Here, we identify a
new role for these proteins in the regulation of mitotic progression and in SAC activation.
MDC1 localizes at mitotic kinetochores following SAC activation in an ATM-dependent
manner. ATM phosphorylates histone H2AX at mitotic kinetochores, and this …