[HTML][HTML] The metastasis suppressor NDRG1 directly regulates androgen receptor signaling in prostate cancer
N-myc-downregulated gene 1 (NDRG1) has potent anticancer effects and inhibits cell
growth, survival, metastasis, and angiogenesis. Previous studies suggested that NDRG1 is
linked to the androgen signaling network, but this mechanistic relationship is unclear.
Considering the crucial role of the androgen receptor (AR) in prostate cancer (PCa)
progression, here we examined for the first time the effect of NDRG1 on AR expression,
activation, and downstream signaling in LNCaP, 22Rv1, and C4-2B PCa cell types. We …
growth, survival, metastasis, and angiogenesis. Previous studies suggested that NDRG1 is
linked to the androgen signaling network, but this mechanistic relationship is unclear.
Considering the crucial role of the androgen receptor (AR) in prostate cancer (PCa)
progression, here we examined for the first time the effect of NDRG1 on AR expression,
activation, and downstream signaling in LNCaP, 22Rv1, and C4-2B PCa cell types. We …