Regulation of ryanodine receptors by FK506 binding proteins
MG Chelu, CI Danila, CP Gilman… - Trends in cardiovascular …, 2004 - Elsevier
Ryanodine receptors (RyRs) are the major sarcoplasmic reticulum calcium-release
channels required for excitation–contraction coupling in skeletal and cardiac muscle.
Mutations in RyRs have been linked to several human diseases. Mutations in the cardiac
isoform of RyR2 are associated with catecholaminergic polymorphic ventricular arrhythmias
(CPVT), and arrhythmogenic right ventricular dysplasia type 2 (ARVD2), whereas mutations
in the skeletal muscle isoform (RyR1) are linked to malignant hyperthermia (MH) and central …
channels required for excitation–contraction coupling in skeletal and cardiac muscle.
Mutations in RyRs have been linked to several human diseases. Mutations in the cardiac
isoform of RyR2 are associated with catecholaminergic polymorphic ventricular arrhythmias
(CPVT), and arrhythmogenic right ventricular dysplasia type 2 (ARVD2), whereas mutations
in the skeletal muscle isoform (RyR1) are linked to malignant hyperthermia (MH) and central …
