Bile acids play a role in colorectal carcinogenesis as evidenced by epidemiological and
experimental studies. Some bile acids stimulate growth of normal colonic and adenoma
cells, but not of colorectal cancer cells. Moreover, bile acids stimulate invasion of colorectal
cancer cells, at least in vitro. One possible mechanism of action is bile acid-induced DNA
binding and transactivation of the activator protein-1 (AP-1) by co-operate activation of
extracellular signal-regulated kinases (ERKs) and PKC signaling. In the present paper, we …