Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears
AH Diacon, RF Patientia, A Venter… - Antimicrobial agents …, 2007 - Am Soc Microbiol
AH Diacon, RF Patientia, A Venter, PD Van Helden, PJ Smith, H McIlleron, JS Maritz…
Antimicrobial agents and chemotherapy, 2007•Am Soc MicrobiolWe studied the early bactericidal activity of twice the standard dose of rifampin in subjects
with pulmonary tuberculosis evidenced by positive smears. The observed mean 2-day
activity was almost double that reported at the standard dose. Further studies are warranted
to establish whether higher rifampin doses might assist in shortening tuberculosis treatment.
with pulmonary tuberculosis evidenced by positive smears. The observed mean 2-day
activity was almost double that reported at the standard dose. Further studies are warranted
to establish whether higher rifampin doses might assist in shortening tuberculosis treatment.
Abstract
We studied the early bactericidal activity of twice the standard dose of rifampin in subjects with pulmonary tuberculosis evidenced by positive smears. The observed mean 2-day activity was almost double that reported at the standard dose. Further studies are warranted to establish whether higher rifampin doses might assist in shortening tuberculosis treatment.
American Society for Microbiology