Cholesterol Is Not an Essential Source of Nutrition for Mycobacterium tuberculosis during Infection
X Yang, J Gao, I Smith, E Dubnau… - Journal of …, 2011 - Am Soc Microbiol
X Yang, J Gao, I Smith, E Dubnau, NS Sampson
Journal of bacteriology, 2011•Am Soc MicrobiolABSTRACT Rv1106c (hsd; 3β-hydroxysteroid dehydrogenase) is required by
Mycobacterium tuberculosis for growth on cholesterol as a sole carbon source, whereas
Rv3409c is not. Mutation of Rv1106c does not reduce Mycobacterium tuberculosis growth in
infected macrophages or guinea pigs. We conclude that cholesterol is not required as a
nutritional source during infection.
Mycobacterium tuberculosis for growth on cholesterol as a sole carbon source, whereas
Rv3409c is not. Mutation of Rv1106c does not reduce Mycobacterium tuberculosis growth in
infected macrophages or guinea pigs. We conclude that cholesterol is not required as a
nutritional source during infection.
Abstract
Rv1106c (hsd; 3β-hydroxysteroid dehydrogenase) is required by Mycobacterium tuberculosis for growth on cholesterol as a sole carbon source, whereas Rv3409c is not. Mutation of Rv1106c does not reduce Mycobacterium tuberculosis growth in infected macrophages or guinea pigs. We conclude that cholesterol is not required as a nutritional source during infection.
American Society for Microbiology