Cholesterol plays a larger role during Mycobacterium tuberculosis in vitro dormancy and reactivation than previously suspected
MD Soto-Ramirez, DA Aguilar-Ayala, L Garcia-Morales… - Tuberculosis, 2017 - Elsevier
It is known that cholesterol plays a key role for Mycobacterium tuberculosis (Mtb) adaptation
and survival within the host, thus contributing to the establishment of dormancy. It has been
extensively demonstrated that fatty acids are the main energy source of Mtb during infection
and dormancy, and it has been proposed that these molecules are implicated in reactivation
of bacilli from a dormant state. We used in vitro models to analyze Mtb gene expression
during dormancy and reactivation when fatty acids and cholesterol are the unique carbon …
and survival within the host, thus contributing to the establishment of dormancy. It has been
extensively demonstrated that fatty acids are the main energy source of Mtb during infection
and dormancy, and it has been proposed that these molecules are implicated in reactivation
of bacilli from a dormant state. We used in vitro models to analyze Mtb gene expression
during dormancy and reactivation when fatty acids and cholesterol are the unique carbon …