Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia
RL Mayer, JD Schwarzmeier, MC Gerner… - Molecular & Cellular …, 2018 - ASBMB
B cell chronic lymphocytic leukemia (B-CLL), the most common type of leukemia in adults, is
still essentially incurable despite the development of novel therapeutic strategies. This
reflects the incomplete understanding of the pathophysiology of this disease. A
comprehensive proteome analysis of primary human B-CLL cells and B cells from younger
as well as elderly healthy donors was performed. For comparison, the chronic B cell
leukemia cell line JVM-13 was also included. A principal component analysis comprising …
still essentially incurable despite the development of novel therapeutic strategies. This
reflects the incomplete understanding of the pathophysiology of this disease. A
comprehensive proteome analysis of primary human B-CLL cells and B cells from younger
as well as elderly healthy donors was performed. For comparison, the chronic B cell
leukemia cell line JVM-13 was also included. A principal component analysis comprising …
