[HTML][HTML] Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia
Stimuli such as inflammation or hypoxia induce cytochrome P450 epoxygenase-mediated
production of arachidonic acid–derived epoxyeicosatrienoic acids (EETs). EETs have
cardioprotective, vasodilatory, angiogenic, anti-inflammatory, and analgesic effects, which
are diminished by EET hydrolysis yielding biologically less active dihydroxyeicosatrienoic
acids (DHETs). Previous in vitro assays have suggested that epoxide hydrolase 2 (EPHX2)
is responsible for nearly all EET hydrolysis. EPHX1, which exhibits slow EET hydrolysis in …
production of arachidonic acid–derived epoxyeicosatrienoic acids (EETs). EETs have
cardioprotective, vasodilatory, angiogenic, anti-inflammatory, and analgesic effects, which
are diminished by EET hydrolysis yielding biologically less active dihydroxyeicosatrienoic
acids (DHETs). Previous in vitro assays have suggested that epoxide hydrolase 2 (EPHX2)
is responsible for nearly all EET hydrolysis. EPHX1, which exhibits slow EET hydrolysis in …
