Soluble epoxide hydrolase dimerization is required for hydrolase activity
JW Nelson, RM Subrahmanyan, SA Summers… - Journal of Biological …, 2013 - ASBMB
Soluble epoxide hydrolase (sEH) plays a key role in the metabolic conversion of the
protective eicosanoid 14, 15-epoxyeicosatrienoic acid to 14, 15-dihydroxyeicosatrienoic
acid. Accordingly, inhibition of sEH hydrolase activity has been shown to be beneficial in
multiple models of cardiovascular diseases, thus identifying sEH as a valuable therapeutic
target. Recently, a common human polymorphism (R287Q) was identified that reduces sEH
hydrolase activity and is localized to the dimerization interface of the protein, suggesting a …
protective eicosanoid 14, 15-epoxyeicosatrienoic acid to 14, 15-dihydroxyeicosatrienoic
acid. Accordingly, inhibition of sEH hydrolase activity has been shown to be beneficial in
multiple models of cardiovascular diseases, thus identifying sEH as a valuable therapeutic
target. Recently, a common human polymorphism (R287Q) was identified that reduces sEH
hydrolase activity and is localized to the dimerization interface of the protein, suggesting a …