IgE class switching and cellular memory

M Akdis, CA Akdis - Nature immunology, 2012 - nature.com
Nature immunology, 2012nature.com
After class switching in naive B cells, memory B cells and plasma cells that produce
immunoglobulin E (IgE+ cells) develop through a germinal-center IgE+ intermediate cell
without an IgG1 phase. In addition, cellular IgE memory resides in IgE+ memory B cells, and
IgG1+ memory B cells are not an important source of IgE memory.
After class switching in naive B cells, memory B cells and plasma cells that produce immunoglobulin E (IgE+ cells) develop through a germinal-center IgE+ intermediate cell without an IgG1 phase. In addition, cellular IgE memory resides in IgE+ memory B cells, and IgG1+ memory B cells are not an important source of IgE memory.
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