Differential boosting of innate and adaptive antiviral responses during pegylated-interferon-alpha therapy of chronic hepatitis B
L Micco, D Peppa, E Loggi, A Schurich, L Jefferson… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: A better understanding of the immunomodulatory effects of
PegIFNα therapy could allow more rational optimisation of future therapeutic approaches in
chronic HBV infection. In this study, we evaluated dynamic changes in the innate and
adaptive arms of the immune system induced by PegIFNα. METHODS: PBMC were obtained
from a cohort of patients with eAg-negative CHB before, during and after PegIFNα treatment.
The number, phenotype and function of global and virus-specific T cells and NK cells were …
PegIFNα therapy could allow more rational optimisation of future therapeutic approaches in
chronic HBV infection. In this study, we evaluated dynamic changes in the innate and
adaptive arms of the immune system induced by PegIFNα. METHODS: PBMC were obtained
from a cohort of patients with eAg-negative CHB before, during and after PegIFNα treatment.
The number, phenotype and function of global and virus-specific T cells and NK cells were …
