Dynamin-related protein 1 deficiency promotes recovery from AKI
The proximal tubule epithelium relies on mitochondrial function for energy, rendering the
kidney highly susceptible to ischemic AKI. Dynamin-related protein 1 (DRP1), a mediator of
mitochondrial fission, regulates mitochondrial function; however, the cell-specific and
temporal role of DRP1 in AKI in vivo is unknown. Using genetic murine models, we found
that proximal tubule–specific deletion of Drp1 prevented the renal ischemia-reperfusion–
induced kidney injury, inflammation, and programmed cell death observed in wild-type mice …
kidney highly susceptible to ischemic AKI. Dynamin-related protein 1 (DRP1), a mediator of
mitochondrial fission, regulates mitochondrial function; however, the cell-specific and
temporal role of DRP1 in AKI in vivo is unknown. Using genetic murine models, we found
that proximal tubule–specific deletion of Drp1 prevented the renal ischemia-reperfusion–
induced kidney injury, inflammation, and programmed cell death observed in wild-type mice …