Antidiuretic action of collecting duct (pro) renin receptor downstream of vasopressin and PGE2 receptor EP4
Within the kidney, the (pro) renin receptor (PRR) is predominantly expressed in the
collecting duct (CD), particularly in intercalated cells, and it is regulated by the PGE 2
receptor EP 4. Notably, EP 4 also controls urinary concentration through regulation of
aquaporin 2 (AQP2). Here, we tested the hypothesis that sequential activation of EP 4 and
PRR determines AQP2 expression in the CD, thus mediating the antidiuretic action of
vasopressin (AVP). Water deprivation (WD) elevated renal PRR expression and urinary …
collecting duct (CD), particularly in intercalated cells, and it is regulated by the PGE 2
receptor EP 4. Notably, EP 4 also controls urinary concentration through regulation of
aquaporin 2 (AQP2). Here, we tested the hypothesis that sequential activation of EP 4 and
PRR determines AQP2 expression in the CD, thus mediating the antidiuretic action of
vasopressin (AVP). Water deprivation (WD) elevated renal PRR expression and urinary …