[PDF][PDF] Bone and muscle endocrine functions: unexpected paradigms of inter-organ communication

G Karsenty, EN Olson - Cell, 2016 - cell.com
Cell, 2016cell.com
Most physiological functions originate with the communication between organs. Mouse
genetics has revived this holistic view of physiology through the identification of inter-organ
communications that are unanticipated, functionally important, and would have been difficult
to uncover otherwise. This Review highlights this point by showing how two tissues usually
not seen as endocrine ones, bone and striated muscles, influence several physiological
processes in a significant manner.
Most physiological functions originate with the communication between organs. Mouse genetics has revived this holistic view of physiology through the identification of inter-organ communications that are unanticipated, functionally important, and would have been difficult to uncover otherwise. This Review highlights this point by showing how two tissues usually not seen as endocrine ones, bone and striated muscles, influence several physiological processes in a significant manner.
cell.com