Neuropeptide FF reduces food intake in rats

T Murase, H Arima, K Kondo, Y Oiso - Peptides, 1996 - Elsevier
The effect of neuropeptide FF (NPFF), a mammalian FMRFamide-like peptide with antiopioid
activity, on food intake was investigated in food-deprived rat. The ICV administration of NPFF
(5 or 10 μg/rat) reduced food intake during the first 60 min after administration. ICV injection
of naloxone (10 or 100 μg/rat), an opioid antagonist, also decreased food intake. However,
the combination of NPFF and naloxone showed no additivity in the anorexigenic effect,
suggesting that NPFF and naloxone reduced food intake by the common mechanism. These …