A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.

JD Mcgarry, GP Mannaerts… - The Journal of clinical …, 1977 - Am Soc Clin Investig
JD Mcgarry, GP Mannaerts, DW Foster
The Journal of clinical investigation, 1977Am Soc Clin Investig
Studied on the oxidation of oleic and octanoic acids to ketone bodies were carried out in
homogenates and in mitochondrial fractions of livers taken from fed and fasted rats. Malonyl-
CoA inhibited ketogenesis from the former but not from the latter substrate. The site of
inhibition appeared to be the carnitine acyltransferase I reaction. The effect was specific and
easily reversible. Inhibitory concentrations were in the range of values obtained in livers
from fed rats by others. It is proposed that malonyl-CoA functions as both precursor for fatty …
Studied on the oxidation of oleic and octanoic acids to ketone bodies were carried out in homogenates and in mitochondrial fractions of livers taken from fed and fasted rats. Malonyl-CoA inhibited ketogenesis from the former but not from the latter substrate. The site of inhibition appeared to be the carnitine acyltransferase I reaction. The effect was specific and easily reversible. Inhibitory concentrations were in the range of values obtained in livers from fed rats by others. It is proposed that malonyl-CoA functions as both precursor for fatty acid synthesis and suppressor of fatty acid oxidation. As such, it might be an important element in the carbohydrate-induced sparing of fatty acid oxidation.
The Journal of Clinical Investigation