The phenomenon of “liver zonation” is a remarkable process by which the liver fulfills its
metabolic functions, involving highly dynamic transcriptional mechanisms. Its understanding
is therefore a challenging issue. Zonation is reflected in heterogeneity of hepatocytes along
the porto-central axis of the liver: periportal hepatocytes, located in the vicinity of the afferent
portal vein, do not express the same metabolic enzymes than pericentral hepatocytes
located near the efferent central vein. This is mainly dictated at the transcriptional level by …