Adaptive thermogenesis is the cellular process transforming chemical energy into heat in
response to cold. A decrease in adaptive thermogenesis is a contributing factor to obesity.
However, the molecular mechanisms responsible for the compromised adaptive
thermogenesis in obese subjects have not yet been elucidated. In this study we
hypothesized that Toll-like receptor 4 (TLR4) activation and subsequent inflammatory
responses are key regulators to suppress adaptive thermogenesis. To test this hypothesis …