Immunohistochemical staining for thyroid transcription factor-1: a helpful aid in discerning primary site of tumor origin in patients with brain metastases
M Srodon, WH Westra - Human pathology, 2002 - Elsevier
Metastatic carcinoma of unknown primary origin is a perplexing but common problem,
accounting for up to 10% to 15% of all solid tumors at presentation. Many of these
metastases presumably arise from primary lung carcinomas, but the morphologic features
and immunohistochemical profile of lung cancer is often too nonspecific to permit
unequivocal confirmation. Thyroid transcription factor-1 (TTF-1) is expressed in lung
adenocarcinomas and thyroid carcinomas but not in adenocarcinomas arising from other …
accounting for up to 10% to 15% of all solid tumors at presentation. Many of these
metastases presumably arise from primary lung carcinomas, but the morphologic features
and immunohistochemical profile of lung cancer is often too nonspecific to permit
unequivocal confirmation. Thyroid transcription factor-1 (TTF-1) is expressed in lung
adenocarcinomas and thyroid carcinomas but not in adenocarcinomas arising from other …