The GAS5 (growth arrest-specific transcript 5) gene fuses to BCL6 as a result of t (1; 3)(q25; q27) in a patient with B-cell lymphoma
Y Nakamura, N Takahashi, E Kakegawa… - Cancer genetics and …, 2008 - Elsevier
The BCL6 gene is frequently disrupted at its 5′ noncoding region by 3q27 chromosomal
translocations in B-cell lymphoma. As a result of translocation, BCL6 is juxtaposed to
reciprocal partners, such as the immunoglobulin (Ig) gene. Besides the Ig loci, multiple non-
Ig partners of the BCL6 translocation have been reported. Here we describe the
identification of the GAS5 (growth arrest-specific transcript 5) gene as a novel partner of the
BCL6 in a patient with diffuse large B-cell lymphoma, harboring the t (1; 3)(q25; q27) …
translocations in B-cell lymphoma. As a result of translocation, BCL6 is juxtaposed to
reciprocal partners, such as the immunoglobulin (Ig) gene. Besides the Ig loci, multiple non-
Ig partners of the BCL6 translocation have been reported. Here we describe the
identification of the GAS5 (growth arrest-specific transcript 5) gene as a novel partner of the
BCL6 in a patient with diffuse large B-cell lymphoma, harboring the t (1; 3)(q25; q27) …