[HTML][HTML] Control of RNA processing by a large non-coding RNA over-expressed in carcinomas
R Lin, M Roychowdhury-Saha, C Black, AT Watt… - FEBS letters, 2011 - Elsevier
R Lin, M Roychowdhury-Saha, C Black, AT Watt, EG Marcusson, SM Freier, TS Edgington
FEBS letters, 2011•ElsevierRNA processing is vital for the high fidelity and diversity of eukaryotic transcriptomes and the
encoded proteomes. However, control of RNA processing is not fully established. Σ RNA is a
class of conserved large non-coding RNAs (murine Hepcarcin; human MALAT-1) up-
regulated in carcinomas. Using antisense technology, we identified that RNA post-
transcriptional modification is the most significant global function of Σ RNA. Specifically,
processing of the pre-mRNAs of genes including Tissue Factor and Endoglin was altered by …
encoded proteomes. However, control of RNA processing is not fully established. Σ RNA is a
class of conserved large non-coding RNAs (murine Hepcarcin; human MALAT-1) up-
regulated in carcinomas. Using antisense technology, we identified that RNA post-
transcriptional modification is the most significant global function of Σ RNA. Specifically,
processing of the pre-mRNAs of genes including Tissue Factor and Endoglin was altered by …
RNA processing is vital for the high fidelity and diversity of eukaryotic transcriptomes and the encoded proteomes. However, control of RNA processing is not fully established. Σ RNA is a class of conserved large non-coding RNAs (murine Hepcarcin; human MALAT-1) up-regulated in carcinomas. Using antisense technology, we identified that RNA post-transcriptional modification is the most significant global function of Σ RNA. Specifically, processing of the pre-mRNAs of genes including Tissue Factor and Endoglin was altered by hydrolysis of Σ RNA/MALAT-1. These results support the hypothesis that Σ RNA/MALAT-1 is a regulatory molecule exerting roles in RNA post-transcriptional modification.
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