[HTML][HTML] Activation of p53 by MEG3 non-coding RNA
Y Zhou, Y Zhong, Y Wang, X Zhang, DL Batista… - Journal of Biological …, 2007 - ASBMB
MEG3 is a maternally expressed imprinted gene suggested to function as a non-coding
RNA. Our previous studies suggest that MEG3 has a function of tumor suppression. The
tumor suppressor p53 plays a central role in tumor suppression and mediates the functions
of many other tumor suppressors. Therefore, we hypothesized that MEG3 functions through
activation of p53. We found that transfection of expression constructs for MEG3 and its
isoforms results in a significant increase in p53 protein levels and dramatically stimulates …
RNA. Our previous studies suggest that MEG3 has a function of tumor suppression. The
tumor suppressor p53 plays a central role in tumor suppression and mediates the functions
of many other tumor suppressors. Therefore, we hypothesized that MEG3 functions through
activation of p53. We found that transfection of expression constructs for MEG3 and its
isoforms results in a significant increase in p53 protein levels and dramatically stimulates …