MicroRNAs and potential target interactions in psoriasis

JR Zibert, MB Løvendorf, T Litman, J Olsen… - Journal of …, 2010 - Elsevier
BACKGROUND: Psoriasis is a chronic inflammatory skin disease often seen in patients with
a genetic susceptibility. MicroRNAs (miRNA) are endogenous, short RNA molecules that
can bind to parts of mRNA target genes, thus inhibiting their translation and causing
accelerated turnover or transcript degradation. MicroRNAs are important in the
pathogenesis of human diseases such as immunological disorders, as they regulate a broad
range of biological processes. OBJECTIVE: We investigated miRNA–mRNA interactions in …