[HTML][HTML] MiR-22-silenced cyclin A expression in colon and liver cancer cells is regulated by bile acid receptor
Because of the significant tumor-suppressive role of microRNA-22 (miR-22), the current
study was designed to understand the regulation of miR-22 and to identify additional
downstream miR-22 targets in liver and colon cells. The data showed that miR-22 was
transcriptionally regulated by bile acid receptor farnesoid X receptor (FXR) through direct
binding to an invert repeat 1 motif located at− 1012 to− 1025 bp upstream from miR-22.
Among the studied primary and secondary bile acids, chenodeoxycholic acid, which has the …
study was designed to understand the regulation of miR-22 and to identify additional
downstream miR-22 targets in liver and colon cells. The data showed that miR-22 was
transcriptionally regulated by bile acid receptor farnesoid X receptor (FXR) through direct
binding to an invert repeat 1 motif located at− 1012 to− 1025 bp upstream from miR-22.
Among the studied primary and secondary bile acids, chenodeoxycholic acid, which has the …
