[HTML][HTML] Discovery of NKT cells and development of NKT cell-targeted anti-tumor immunotherapy
M Taniguchi, M Harada, N Dashtsoodol… - Proceedings of the …, 2015 - jstage.jst.go.jp
M Taniguchi, M Harada, N Dashtsoodol, K Satoshi
Proceedings of the Japan Academy, Series B, 2015•jstage.jst.go.jpAbstract Natural Killer T (NKT) cells are unique lymphocytes characterized by their
expression of a single invariant antigen receptor encoded by Vα14Jα18 in mice and
Vα24Jα18 in humans, which recognizes glycolipid antigens in association with the
monomorphic CD1d molecule. NKT cells mediate adjuvant activity to activate both CD8T
cells to kill MHC-positive tumor cells and NK cells to eliminate MHC-negative tumor at the
same time in patients, resulting in the complete eradication of tumors without relapse …
expression of a single invariant antigen receptor encoded by Vα14Jα18 in mice and
Vα24Jα18 in humans, which recognizes glycolipid antigens in association with the
monomorphic CD1d molecule. NKT cells mediate adjuvant activity to activate both CD8T
cells to kill MHC-positive tumor cells and NK cells to eliminate MHC-negative tumor at the
same time in patients, resulting in the complete eradication of tumors without relapse …
Abstract
Natural Killer T (NKT) cells are unique lymphocytes characterized by their expression of a single invariant antigen receptor encoded by Vα14Jα18 in mice and Vα24Jα18 in humans, which recognizes glycolipid antigens in association with the monomorphic CD1d molecule. NKT cells mediate adjuvant activity to activate both CD8T cells to kill MHC-positive tumor cells and NK cells to eliminate MHC-negative tumor at the same time in patients, resulting in the complete eradication of tumors without relapse. Therefore, the NKT cell-targeted therapy can be applied to any type of tumor and also to anyone individual, regardless of HLA type.
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