Lower liver transplant success in females: gender differences in metabolic response to global ischemia

C Wittnich, MP Belanger, N Askin, C Boscarino… - Transplantation …, 2004 - Elsevier
BACKGROUND: Research has shown that gender plays a significant role in the metabolic
processes of different organs and that transplanting livers of females into male or female
recipients has significantly higher failure rates. To understand why, this study examined
whether gender differences exist in various metabolic responses of livers to ischemia.
METHODS: The following metabolic liver parameters in Sprague-Dawley rats (male, n= 14;
and female, n= 18) were examined; adenosine triphosphate (ATP) and lactate expressed as …